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Journal Abstract
 
Fusidic acid resistance among staphylococci strains isolated from clinical specimens in a general hospital
Türkan Toka Özer 1, Erkan Yula 2, Alicem Tekin 3, Özcan Deveci 4
1 - Kızıltepe General Hospital, Department of Medical Microbiology, Mardin, Turkey
2 - Mustafa Kemal University, Medical Faculty, Department of Medical Microbiology, Hatay, Turkey
3 - Dicle University, Medical Faculty, Department of Medical Microbiology, Diyarbakır, Turkey
4 - Dicle University, Medical Faculty, Department of Infectious Diseases, Diyarbakır, Turkey
Dicle Med J 2012; 39(1):1-5
ICID: 986766
Article type: Original article
IC™ Value: 3.00
Abstract provided by Publisher
 
Objectives: The aim of this study was to investigate in vitro
susceptibility of fusidic acid to clinic isolates of staphylococci.
Materials and methods: The forty-one coagulase negative
staphylococci (CNS) and 18 Staphylococcus aureus
strains isolated from various clinical specimens were included
in this study. Staphylococci isolates were identified
by conventional methods such as colony morphology
onto medium, gram staining, catalase and coagulase
tests. According to “Clinical and Laboratory Standards Institute
(CLSI)” criteria, antimicrobial susceptibility testing
of isolates was performed by Kirby-Bauer’s disk diffusion
method.
Results: The seventy-two percent of the isolated S.aureus
were defined as methicillin sensitive-S.aureus (MSSA),
28% of the isolated S.aureus were defined as methicillin
resistant-S.aureus (MRSA). The difference among fusidic
acid susceptibility rates of MSSA and MRSA strains was
not statistically significant (p=0.305). The twenty-nine percent
of the isolated CNS were defined as methicillin sensitive-
CNS (MS-CNS), 71% of the isolated CNS were defined
as methicillin resistant-CNS (MR-CNS). There was
no statistically significant difference between MS-CNS
and MR-CNS strains for fusidic acid susceptibility rates
(p=0.490). But the difference among fusidic acid susceptibility
rates of CNS and S.aureus strains was statistically
significant (p<0.001). CNS strains were found more resistance
than S.aureus strains for fusidic acid.
Conclusion: In this study, the resistance rates were
detected to increase for fusidic acid along with methicillin
resistance. Among CNS isolates, fusidic acid resistance
rates were significantly more elevated than that for
S.aureus. Fusidic acid remains as an alternative in the
treatment of infections due to staphylococci.

ICID 986766
 
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