Evaluation of interleukin-2 and tumor necrosis factor-α levels in patients with lichen planus Derya Uçmak 1, Gökçen Balcı 1, Mehmet Harman 1 1 - Dicle University, Faculty of Medicine, Department of Dermatology, Diyarbakır, Turkey
Dicle Med J 2012; 39(1):6-8 ICID: 986794
Article type: Original article
IC™ Value: 3.00
Abstract provided by Publisher
Objectives: Lichen planus is an immunologic disease
mediated by lymphocytes in which T lymphocytes target
at basal cells. It is believed that TNF-α that is released
from T lymphocytes and keratinocytes plays a key role in
the starting and progression of lichen planus by inducing
apoptosis. MHC Class-I antigens on basal keratinocytes
and interleukin-2 (IL-2) and IFN-gamma (γ) that are produced
from CD4+ T cells stimulate the apoptosis of keratinocytes
in lichen planus. The aim of this study was to
measured the IL-2 and TNF-α levels in peripheral blood
from patients with Lichen planus.
Materials and methods: A total of 26 lichen planus patients
(18 females, 8 males) that applied to the dermatology
policlinics in Dicle University Hosspital between 2004
and 2006 and a healthy control group were included in
the study. Serum IL-2 and TNF-α levels were measured
by using Immulate 1000 solid phase and two-site chemiluminescent
immunometric assay method. The results of
patients and control group were compared.
Results: Level of IL-2 (1172.615 ± 774.967) and TNF-α
(13.361 ± 5.638) were higher in lichen planus to compared
controls. IL-2 and TNF-α levels in the patient group were
found to be significantly high statistically compared to
health control group, respectively p=0.004 and p<0.001.
Conclusion: The high levels of IL-2 and TNF-α in lichen
planus patients support the role of immunity in the pathogenesis
of the disease.