Comparison of the effects of antiglaucomatous fixed combinations and patients compliance: dorzolamide-timolol maleate and latanoprost-timolol maleate İrfan Uzun 1, Kubilay Çetinkaya 1 1 - Trabzon Numune Eğitim ve Araştırma Hastanesi, Göz Kliniği, Trabzon, Türkiye
Dicle Med J 2012; 39(1):61-69 ICID: 987023
Article type: Editorial
IC™ Value: 2.40
Abstract provided by Publisher
Objectives: We aimed to compare the effects of fixed
combinations of dorzolamide/timolol maleate (DTFC) and
latanoprost/timolol maleate (LTFC) at primary open angle
glaucoma patients and assess the patient compliance to
Materials and Methods: Forty-four eyes of 24 patients
taking LTFC, 35 eyes of 24 patients taking DTFC and totally
79 eyes of 48 patients were included in this study.
Patients were followed for 6 months. At 3rd month, diurnal
intraocular pressure (IOP) fluctuations were assessed.
Perimetry and retinal nerve fiber layer (RNFL) analyze
were repeated at 6th month.
Results: Both medicines had efficiently controlled the
IOP and diurnal fluctuations and statistically no significant
difference was observed (p>0.05). Perimetric and RNFL
measurements were not different in both groups(p>0.05).
When we have compared the results of baseline and 6th
months, MD and sLV values decreased, RNFL in some
cases increased on the other hand we have also observed
a decrease in some cases(p<0.05). Ocular irritation was
the most common side effect in both groups and there
was no statistically significant difference between the
groups by means of side effects.When compliance and
adherence were assessed, there was no statistically significant
difference between the groups (p>0.05). Most of
the patients did not forget to take their medicines (DTSK
%54.2 and LTSK %66.7) and in following visits, compliance
and adherence were improved in both groups. It
is detected that duration of medicine use may affect the
Conclusion: It is observed that two medicines controlled
the IOP and diurnal fluctuations clinically efficient and effectively,
had reasonable side effects and had high patient
compliance to treatment.