Dicle Medical Journal
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Journal Abstract
A case of primary gastric choriocarcinoma and a review of the Turkish literature:An extremely rare carcinoma of the stomach
Cüneyt Kırkıl 1, Koray Karabulut 1, Erhan Aygen 1, Yavuz Selim İlhan 1, Mesut Yur 1, İbrahim Hanifi Özercan 2
1 - Fırat University, Medical School, Department of General Surgery, Elazığ, Turkey
2 - Fırat University, Medical School, Department of Pathology, Elazığ, Turkey
Dicle Med J 2012; 39(1):105-109
ICID: 987124
Article type: Case report
IC™ Value: 1.80
Abstract provided by Publisher
Primary choriocarcinoma of the stomach is an extremely
rare and highly malignant tumor. A 60 years old man visited
another hospital for the chief complaint of the stomachache
and black stools. A large ulcero-vegetative tumor
occupying the gastric body and antrum was seen in the
upper gastrointestinal endoscopy. It was diagnosed as
gastric adenocarcinoma by endoscopic biopsy. The patient
admitted to our hospital for treatment. The patient
was assessed as a gastric adenocarcinoma complicated
with hemorrhage. In the exploration, it was observed that
the mass arising from gastric body was invaded the transverse
colon and pancreas. The lymphadenopaties in the
celiac axis were conglomerated and had invaded the celiac
vessels. A subtotal gastrectomy and an extended right
hemicolectomy were performed for palliation. In pathological
findings, typical characteristics of two cell pattern consisting
of syncytiotrophoblasts and cytotrophoblasts were
observed. The tumor consisted of only choriocarcinoma.
For the definite diagnosis of choriocarcinoma, immunohistochemi-
cal tests were performed. Beta-HCG and
EMA staining were positive. The patient was invited for
control because of gastric choriocarcinoma three weeks
later surgery. His serum beta-HCG level was 458 mIU/mL
(normal range, <0.5 mIU/mL). For the differantiation from
the primary choriocarcinoma in the testis or mediastinum,
testicular ultrasonography and chest CT were performed.
Abnormal findings were not detected in the tests, so it
was diagnosed as primary gastric choriocarcinoma. The
patient refused chemotherapy. Three months later, he
had inguinal lymphadenopaties and multiple metastases
in lung. He died 5 months after surgery because of respiratory

ICID 987124

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